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Food decreases the extent of and slightly delays the absorption of metformin, as shown by approximately a 40 lower mean peak plasma concentration c max , a 25 lower area under the plasma concentration versus time curve auc , and a 35-minute prolongation of time to peak plasma concentration t max following adminis tration of a single 850 mg tablet of amaryl-mp metformin with food, compared to the same tablet strength administered fasting.

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