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11 Mayıs 2018

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In stable patients converted from prograf capsules twice daily to advagraf once daily on a 1 1 mg mg total daily dose basis, the systemic exposure to tacrolimus auc 0-24 for advagraf was approximately 10 lower than that for prograf.

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trial contained a third arm of a combination regimen of sirolimus, 2 mg per day, and full-dose prograf; however, this regimen was associated with increased risk of wound healing complications, renal function impairment, and insulin-dependent post-transplant diabetes mellitus, and is not recommended see warnings and precautions .

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