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In study 1, for patients who completed to week 12, 69 of paroxetine-treated patients compared to 29 of placebo-treated patients were cgi improvement responders.

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drugs metabolized by cyp2d6 many drugs, including most drugs effective in the treatment of major depressive disorder paroxetine, other ssris and many tricyclics , are metabolized by the cytochrome p450 isozyme cyp2d6.

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patients should be cautioned that paroxetine hydrochloride controlled-release tablets should not be chewed or crushed, and should be swallowed whole.


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