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Do not take this medicine with any of the following medications -cidofovir -ketorolac -methotrexate this medicine may also interact with the following medications -alcohol -alendronate -antacids with magnesium -aspirin and aspirin-like medicines -diuretics -herbal products that contain feverfew, garlic, ginger, or ginkgo biloba -lithium -medicines for high blood pressure -medicines that treat or prevent blood clots like warfarin -other nsaids, medicines for pain and inflammation, like ibuprofen or naproxen -pemetrexed.

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a case of tonic-clonic seizure was observed in a child with acute lymphoblastic leukemia a few hours after a 24-hour infusion of high-dose methotrexate mtx; 5 g m2 .

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