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Hydroxychloroquine moderate hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown.

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pharmacokinetic analysis of the oral and subcutaneous formulations showed that while oral methotrexate had a plateau with the 15 mg dose, drug concentrations for the subcutaneous drug continued to rise above that level, with relative bioavailability levels versus the oral drug of 121 , 114 , 131 , and 141 for the 10, 15, 20, and 25 mg doses, respectively.

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do not take this medicine with any of the following medications -atazanavir -nelfinavir this medicine may also interact with the following medications -amiophylline or theophylline -amoxicillin -ampicillin -clarithromycin -cyclosporine -diazepam -digoxin -diuretics -iron salts -itraconazole, ketoconazole, voriconazole, or other prescription medicines for fungus or yeast infections -methotrexate -phenytoin -warfarin.

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otrexup contains methotrexate, a folate analog metabolic inhibitor.


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